Death education: The importance of terror management theory and of the active methods

Death education courses (DECs) prepare healthcare students to man- age future relationships with end-of-life (EOL) patients and their relatives. It would be better for DECs to use active methodologies, for example, creative arts therapies and constructivist and narrative techniques. Research should longitudinally monitor students who have complet- ed a DEC to check their levels of willingness to work in palliative care and their levels of work satisfaction versus burn-out in both the EOL and other hospital wards after they become healthcare professionals

Eternity between a novel theology and a new science from giordano bruno to emanuele severino

The article presents the continuity between two Italian thinkers who have undergone a Catholic Inquisition process: The modern Giordano Bruno and the contemporary Emanuele Severino. The aim of this essay is not to make a comparison between the two philosophers but rather to study how the former passed the baton through history to Severino, in a way that was useful in refunding the relationships between Theology and Science. In particular, it describes how Severino completed what Bruno had only sketched. The ideas of eternity are discussed with respect to God, and they are related to the contraposition between Metaphysics and contemporary thought, from which the conflict between Theology and Science was derived in modernity, particularly after the immolation of Bruno. The article aims to address a number of aspects that unify many elements of Italian philosophy and the reasons why the Catholic Inquisition had to fight against it. The overall focus is on the originality of Severino and considers his philosophy as the basis of a possible \u201eparadigm shift\u201f for both Theology and Science. The theoretical treatise shows how Severino\u201fs indication of eternity can solve many aspects of the clash between Theology and Science, substantially refunding both of them

Language re-discovered: A death education intervention in the net between kindergarten, family and territory

The article presents the positive results of a death education experience, realized owing to a collaboration between school, family and territory. The project, with the scope of reflecting on topics of death and spirituality, included 46 children of 5 from kindergarten and 50 parents, and then mobilizing the entire community. Social services and public administration had a special role in this, aiming to guarantee the necessary support for the families in the existential reflections. The experience was monitored with participatory observation, via interviews and questionnaires. The children answered questions regarding death and spirituality during an open and sincere conversation with the teachers. The parents, who at home talked about certain pre-defined teams with the children, were asked to give their informed consent and were given a questionnaire with open questions ex-ante/ ex-post. All data were processed via qualitative analysis of the texts. The results are truly positive, showing that children are capable of facing the problem of death and are able to acquire a certain representation of the spiritual dimension. The parents, who in the beginning demonstrated some anxiety, eventually were greatly satisfied and expressed their willingness to continue to search for the connection between death and transcendence

Students’ Confidence and Interest in Palliative and Bereavement Care: A European Study

As part of a European Erasmus Plus project entitled Death Education for Palliative Psychology, this study assessed the ways in which Master’s Degree students in psychology and the creative arts therapies self-rated their confidence and interest in death education and palliative and bereavement care. In five countries (Austria, Israel, Italy, Poland, Romania), 344 students completed an online questionnaire, and 37 students were interviewed to better understand their views, interest, and confidence. The results revealed some significant differences between countries, and showed that older respondents with previous experience as formal caregivers for end-of-life clients showed greater interest in obtaining practical clinical competence in these fields. A mediation analysis indicated that students’ previous care experiences and past loss experiences were related to students’ current interest in death education and palliative and bereavement care through the mediation of their sense of confidence in this field. The qualitative findings identified five shared themes: life and death, learning about death, the psychological burden, personal experience and robust training, and four key training needs. Overall, students’ interest in studying and working with terminal illness and death are rooted in internal resources, a preliminary sense of confidence, but also external requirements

Role of serum-free light chain assay for defining response and progression in immunoglobulin secretory multiple myeloma

The International Myeloma Working Group (IMWG) guidelines recommend using electrophoresis and immunofixation to define response and progressive disease (PD) in immunoglobulin (Ig) secretory multiple myeloma (Ig-MM), whereas the role of serum-free light chain (sFLC) is controversial. We retrospectively analyzed the value of adding sFLC assays in the definition of response and PD according to IMWG criteria in 339 Ig-MM patients treated with a first-line novel agent-based therapy (median follow-up 54 months). sFLC PD was defined according to conventional criteria plus increased sFLC levels, or sFLC escape (sFLCe); progression/sFLCe-free survival (ePFS) was the time from the start of treatment to the date of first PD or sFLCe, or death; overall survival after PD/sFLCe (OS after Pe) was the time from first PD or sFLCe to the date of death. 148 (44%) patients achieved a complete response and 198 (60%) a normal sFLC ratio (sFLCR). sFLCR normalization was an independent prognostic factor for extended PFS (HR = 0.46, p = 0.001) and OS (HR = 0.47, p = 0.006) by multivariable analysis. 175 (52%) patients experienced PD according to the IMWG criteria, whereas 180 (53%) experienced PD or sFLCe. Overall, a sFLCe was observed in 31 (9%) patients. Median PFS and ePFS were both equal to 36 (95% CI = 32–42, and 32–40, respectively) months. sFLC PD adversely affected the OS after Pe compared to PD with increasing monoclonal Ig only (HR = 0.52, p = 0.012). Our results support the inclusion of the sFLC assay for defining response and PD in Ig-MM

No evidence of break-up effects on the fusion of 9Be with medium-light nuclei

AbstractFusion cross sections were measured for the 9Be+27Al and 19F+9Be, 12C systems, at energies above the Coulomb barrier, in order to investigate the possible effect of fusion hindrance due to the break-up of the weakly bound nuclei. Comparisons with one-dimensional barrier penetration models and with other similar systems, where no break-up is expected to occur, show no evidence of fusion hindrance

FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth

The mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids